100 Days Mission Mpox Clock: Day 60 (minor update)
The 100 Days Mission (100DM) clock for mpox started on 14th August 2024, following the declaration of mpox a public health emergency of international concern (PHEIC) by WHO. Today we are publishing the Day 60 update on mpox DTV availability. Leading up to Day 100 on 21st November, IPPS will provide updates every 15 days (alternating between major and minor) on the status and progress of mpox DTV availability. The major updates provide detailed deep dives into each tool and highlight specific priority actions to ensure products are available to those who need them. Minor updates like today’s simply track factual changes to the indicators in our tracker and highlight any major developments in the past 15 days.
These updates are intended to support the work of partners and key initiatives and are developed in consultation with implementing partners of the 100DM. We are open to feedback on the accuracy of our data, please get in touch (info@ippsecretariat.org) if you have information to share.
Previous updates:
Please find the latest updates at https://ippsecretariat.org/news/
Key Developments
Overview: the status of DTVs
Diagnostics
Therapeutics
Vaccines
Supporting Resources on Mpox Response – New
- WHO lists first mpox in vitro diagnostic (Abbott Molecular Inc.’s Alinity M MPXV assay) under Emergency Use Listing
- WHO reports that the Democratic Republic of Congo (DRC) is decentralising mpox testing to increase diagnostic speeds
- INTREPID Alliance has published their third edition of the Antiviral Clinical and Preclinical Development Landscape, which now includes mpox
- Vaccination begins in DRC
- 5,420 doses of MVA-BN have been delivered to Rwanda
- WHO Global Advisory Committee on Vaccine Safety (GACVS) reviews mpox vaccine safety data (MVA-BN and LC16m8), emphasizing the need for enhanced monitoring in high-risk populations
- New Outbreaks Page on the Pandemic PACT Website includes a dedicated Mpox Outbreak Page which offer real-time tracking of research funding and regularly updated outbreak summary reports
Supporting Resources on Mpox Response – Previous
- FIND published a protocol for the evaluation of the Mpox diagnostics (POCT and RDTs)
- Africa CDC and FIND published recommendations for Mpox Molecular Diagnostic Tests(RT-PCR)
- WHO launched a global Strategic Preparedness and Response Plan to stop outbreaks of human-to-human transmission of mpox through coordinated global, regional, and national efforts.
- Africa CDC published Mpox Continental Preparedness and Response Plan for Africa
- FIND launched Request for Proposal for mpox diagnostics evaluation and accelerated development in LMICs.
- FIND published results from 1st round of evaluations for point-of-care tests – results suggest that POC molecular tests perform better than RDTs.
- WHO prequalified the first vaccine against mpox
- WHO and partners established an access and allocation mechanism (AAM) for mpox vaccines, treatments, tests