We acknowledge the conclusion of the 2025 G20 Presidency of South Africa and welcome the Leaders’ Declaration. The outcome of South Africa’s presidency serves as an important contribution to advancing multilateral collaboration, equity, and scientific innovation in global health. The Declaration reflects renewed momentum for coordinated international action to strengthen pandemic prevention, preparedness, and response (PPPR).
We applaud G20 Health Ministers for resolving to foster scientific collaboration to accelerate the development, scale up and equitable access to safe and effective vaccines, therapeutics and diagnostics (VTDs) across all regions, as rapidly as possible in the face of an epidemic or pandemic threat.
The 100 Days Mission, the global target to ensure safe, effective, and affordable VTDs are ready and available for scale up within 100 days of a pandemic threat being identified, continues to serve as a guiding benchmark for this ambition. Achieving it will require deeper coordination across R&D, manufacturing, and regulatory systems, strong commitment to embedding equitable access provisions across the innovation lifecycle, and sustained political and financial commitment from G20 Member States.
Yet, as illustrated in the 100 Days Mission Scorecard, the limited pipeline of global vaccines, diagnostics and in particular therapeutics, leaves the world vulnerable to the next viral threat. Accelerated investment in broad-spectrum antivirals, monoclonal antibodies, platform technology, and clinical trial networks, alongside R&D in vaccines and diagnostics, should therefore be a priority for the international community. Partners across the 100 Days Mission are working towards setting up the necessary enabling elements and programs to help address such gaps, with international support.
We commend the Declaration’s support for the Pandemic Agreement and the ongoing Pathogen Access and Benefit-Sharing (PABS) negotiations. This normative framework is essential to ensuring that the benefits of scientific progress – including for pandemic countermeasures – are accessible to all, regardless of geography or income.
The G20’s determination to build resilient, equitable, sustainable, and inclusive health systems, guided by the climate-health nexus and a One Health approach, is a welcome recognition of the interconnected challenges we face.
Finally, we underline the need for long-term investment to strengthen geo-diversified, local and regional, sustainable research & development, manufacturing, and delivery capacity. This is vital to enable rapid scale-up of pandemic-related health products and to ensure global readiness for future outbreaks.
In support of South Africa’s G20 Presidency, CEPI and RVMC, with partners such as Unitaid and IPPS, co-hosted a series of technical sessions bringing together global leaders, scientists, and policymakers to advance pandemic prevention, preparedness, and response (PPR). Discussions focused on operationalising the 100 Days Mission, enhancing regulatory coordination, and investing in equitable access, regionalized manufacturing, data-sharing, antigen libraries, AI-enabled early warning systems, and tracking progress. To put these principles into practice, CEPI and partners led a 100 Days Mission Simulation Exercise, highlighting the urgency of preparedness and the need for coordinated, end-to-end readiness across the global health ecosystem.
Looking ahead to the UN High-Level Meeting (UNHLM) on PPR and continued engagement through the G7 and G20 in 2026, it is vital that epidemic and pandemic preparedness remains high on the global political agenda. The 100 Days Mission partners and community stands ready to support these efforts and to work with governments, civil society, and the private sector to deliver on our shared ambition: a world better equipped to prevent, prepare for, and respond to future pandemics.
Endorsing 100 Days Mission partner organisations:
- Coalition for Epidemic Preparedness Innovations (CEPI)
- Drugs for Neglected Diseases initiative (DNDi)
- FIND
- Impact Global Health
- International Pandemic Preparedness Secretariat (IPPS)
- Pandemic Sciences Institute
- READDI
- Regionalized Vaccine Manufacturing Collaborative (RVMC)
- Resilience Action Network Africa (RANA)
- Resilience Action Network International (rani)
- South African Medical Research Agency (SAMRC)
- Unitaid
ENDS